Use Boltz from Codex for biomolecular modeling workflows: predict structure and binding for protein, RNA, DNA, and ligand complexes; rank small-molecule or protein libraries against targets; and design novel small molecules, peptides, antibodies, nanobodies, or custom protein binders with structures and confidence metrics.
Install
- 1Add it in ChatGPT
Open Plugins in the ChatGPT sidebar (web or desktop), search for “Boltz” and select +. You'll be asked to sign in to any connected service on first use. Then type @ in a chat to call it.
Skills 8
- Boltz Check Status
Inspect Boltz jobs and recover outputs
- Boltz CLI Setup
Install, update, verify, and authenticate boltz-api
- Boltz Protein Design
Design peptide or antibody binders
- Boltz Protein Screen
Screen protein binders against a target
- Boltz Small Molecule ADME
Predict ADME (solubility, permeability, logD) from SMILES
- Boltz Small Molecule Design
Design novel ligands for a protein target
- Boltz Small Molecule Screen
Screen SMILES libraries against protein targets
- Boltz Structure and Binding
Predict complexes and score Boltz binding jobs
Things to ask
- “Predict EGFR L858R binding to osimertinib”
- “Design nanobodies for a SARS-CoV-2 RBD epitope”
- “Design selective JAK2 binders from Enamine REAL”
Disconnect or uninstall
- 1In ChatGPT
Disconnect an account in Settings → Apps or Plugins. To remove the plugin itself, open Boltz in the Plugin Directory and select Uninstall plugin. Uninstalling can disconnect every account connected through it, and plugins your workspace installs may not offer the option.
- 2In Codex
Run /plugins in the Codex CLI, select the plugin and uninstall it, or press Space to turn it off.