# Boltz (ChatGPT Plugin)

> Predict structures, screen molecules and proteins, and design binders

- Type: plugin
- Publisher: Boltz (official)
- Categories: Research, Design
- Website: https://chatgpt.com/plugins/Plugin_146eca281b788191ba8a689a3a96f977
- Open in ChatGPT: https://chatgpt.com/plugins/Plugin_146eca281b788191ba8a689a3a96f977
- Version: 0.1.1
- Listed: 2026-10-04

## About

Use Boltz from Codex for biomolecular modeling workflows: predict structure and binding for protein, RNA, DNA, and ligand complexes; rank small-molecule or protein libraries against targets; and design novel small molecules, peptides, antibodies, nanobodies, or custom protein binders with structures and confidence metrics.

## Install

1. **Add it in ChatGPT** Open Plugins in the ChatGPT sidebar (web or desktop), search for “Boltz” and select +. You'll be asked to sign in to any connected service on first use. Then type @ in a chat to call it.

## Disconnect or uninstall

1. **In ChatGPT** Disconnect an account in Settings → Apps or Plugins. To remove the plugin itself, open Boltz in the Plugin Directory and select Uninstall plugin. Uninstalling can disconnect every account connected through it, and plugins your workspace installs may not offer the option.

2. **In Codex** Run /plugins in the Codex CLI, select the plugin and uninstall it, or press Space to turn it off.

## Skills

- **Boltz Check Status**: Inspect Boltz jobs and recover outputs
- **Boltz CLI Setup**: Install, update, verify, and authenticate boltz-api
- **Boltz Protein Design**: Design peptide or antibody binders
- **Boltz Protein Screen**: Screen protein binders against a target
- **Boltz Small Molecule ADME**: Predict ADME (solubility, permeability, logD) from SMILES
- **Boltz Small Molecule Design**: Design novel ligands for a protein target
- **Boltz Small Molecule Screen**: Screen SMILES libraries against protein targets
- **Boltz Structure and Binding**: Predict complexes and score Boltz binding jobs

## Example prompts

- "Predict EGFR L858R binding to osimertinib"
- "Design nanobodies for a SARS-CoV-2 RBD epitope"
- "Design selective JAK2 binders from Enamine REAL"

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Source: https://chatgptplugins.directory/plugins/boltz · Index: https://chatgptplugins.directory/llms.txt · Independent and community-run. Not affiliated with or endorsed by OpenAI. ChatGPT is a trademark of OpenAI.